Constraints for the quality of data to be suitable for automatic network reconstruction. The algorithm requires that the time course of the considered components is known, no matter whether the data are boolean or continuous (and are subsequently discretized) as only those changes are considered that in fact are reflected by the data set. a) The number of time points measured is so low that the time course of the signal is not reflected with a sufficient resolution in detail and interpolation of the data points may mislead the algorithm as phases of formation and decay of the component are missed. b) The number of time points is sufficiently high in order to correctly reflect the time course of the component.
Durzinsky et al. BMC Systems Biology 2011 5:113 doi:10.1186/1752-0509-5-113