Peripheral building block hypotheses predicted in inconsistent directions with observed cell proliferation. The expected direction of a prediction in the table is based on the known biological role(s) for a given hypothesis, and is shown for all nodes in model. However, because there were no hypotheses in the core Cell Cycle block that were predicted in inconsistent directions, the hypotheses shown in this table are all from peripheral blocks (orange and white blocks in Figure 5). The arrows above the data set names (RhoA, CTNNB1, NR3C1, and EIF4G1) denote the direction in which proliferation was observed to change in the respective experiments.
Westra et al. BMC Systems Biology 2011 5:105 doi:10.1186/1752-0509-5-105