Schematic overview of the "building block" framework used to construct the network. Five "building blocks", each representing areas of biology known to be important for regulating lung cell proliferation, were used as a conceptual guide to construct the network. The Cell Cycle, containing the signaling elements most proximal to driving entry/exit from a proliferative state, was the central block, while connections from four other peripheral building blocks (Growth Factors, Cell Interaction, Epigenetics and Intra- and Extracellular (IC/EC) Signaling) to the Cell Cycle block were also used to construct the network. Due to the size and complexity of the IC/EC block, it was further divided into 11 sub-networks, each focused on a distinct area of cellular signaling related to regulating lung cell proliferation.
Westra et al. BMC Systems Biology 2011 5:105 doi:10.1186/1752-0509-5-105