Table 1

Noise and haploinsufficiency in different loop structures

Network Type

Network Type

a

b

c


1

X deficient

Y deficient

0

+

0

-

+

+

2

X deficient

Y deficient

++

+

-

+

++

+

3

X deficient

Y deficient

0

++

++

++

0

++


Effect of Gaussian noise and haploinsufficiency on disease dynamics with different positive feedback loop structures. ++ indicates early, irreversible and severe disease onset; + indicates disease onset is variable and slightly suppressed; - are cases where disease fluctuates randomly, but reversibly and is suppressed as soon as the appropriate protein rises or falls; 0 indicates no disease occurs.

Bosl and Li BMC Systems Biology 2010 4:93   doi:10.1186/1752-0509-4-93

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