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Open Access Research article

Ordered structure of the transcription network inherited from the yeast whole-genome duplication

Diana Fusco12, Luigi Grassi3, Bruno Bassetti14, Michele Caselle35 and Marco Cosentino Lagomarsino16*

Author Affiliations

1 Università degli Studi di Milano, Dip. Fisica. Via Celoria 16, 20133 Milano, Italy

2 Duke University, Program in Computational Biology and Bioinformatics, North Building, 470 Research Drive, Durham NC 27708, USA

3 Università degli Studi di Torino, Dip. Fisica Teorica, Via Giuria 1, 10125 Torino, Italy

4 I.N.F.N. Milano, Via Celoria 16, 20133 Milano, Italy

5 I.N.F.N. Torino, Via Giuria 1, 10125 Torino, Italy

6 Genomic Physics Group, FRE 3214 CNRS "Microorganism Genomics" and University Pierre et Marie Curie, 15 rue de l'École de Médecine, 75006, Paris, France

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BMC Systems Biology 2010, 4:77  doi:10.1186/1752-0509-4-77

Published: 3 June 2010

Abstract

Background

Gene duplication, a major evolutionary path to genomic innovation, can occur at the scale of an entire genome. One such "whole-genome duplication" (WGD) event among the Ascomycota fungi gave rise to genes with distinct biological properties compared to small-scale duplications.

Results

We studied the evolution of transcriptional interactions of whole-genome duplicates, to understand how they are wired into the yeast regulatory system. Our work combines network analysis and modeling of the large-scale structure of the interactions stemming from the WGD.

Conclusions

The results uncover the WGD as a major source for the evolution of a complex interconnected block of transcriptional pathways. The inheritance of interactions among WGD duplicates follows elementary "duplication subgraphs", relating ancestral interactions with newly formed ones. Duplication subgraphs are correlated with their neighbours and give rise to higher order circuits with two elementary properties: newly formed transcriptional pathways remain connected (paths are not broken), and are preferentially cross-connected with ancestral ones. The result is a coherent and connected "WGD-network", where duplication subgraphs are arranged in an astonishingly ordered configuration.