Table 4 |
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Partial flux control coefficients for lactate dehydrogenase (r18) and oxidative phosphorylation (r41) |
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r18 |
r41 |
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Partial flux control coefficient through |
Partial flux control coefficient through |
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|
Enzyme |
NADin |
PYRin |
LACin |
NADHin |
Flux control coefficient |
ATPin |
NADin |
ADPin |
NADHin |
Flux control coefficient |
|
|
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|
r1 |
0.011 |
0.032 |
-0.002 |
0.043 |
0.084 |
-0.012 |
0.001 |
-0.060 |
0.042 |
-0.028 |
|
r2 |
0.009 |
0.014 |
-0.001 |
0.038 |
0.059 |
-0.007 |
0.001 |
-0.034 |
0.037 |
-0.003 |
|
r3 |
0.011 |
0.017 |
-0.002 |
0.044 |
0.071 |
-0.008 |
0.002 |
-0.041 |
0.044 |
-0.005 |
|
r4 |
0.014 |
0.022 |
-0.002 |
0.056 |
0.089 |
-0.011 |
0.002 |
-0.052 |
0.055 |
-0.006 |
|
r5 |
0.002 |
0.003 |
0.000 |
0.008 |
0.012 |
-0.001 |
0.000 |
-0.007 |
0.008 |
-0.001 |
|
r6 |
0.032 |
0.050 |
-0.005 |
0.132 |
0.209 |
-0.025 |
0.005 |
-0.124 |
0.129 |
-0.015 |
|
r7 |
0.000 |
0.001 |
0.000 |
0.002 |
0.003 |
0.000 |
0.000 |
-0.002 |
0.002 |
0.000 |
|
r8 |
0.000 |
0.012 |
0.000 |
-0.002 |
0.009 |
-0.001 |
0.000 |
-0.005 |
-0.002 |
-0.008 |
|
r9 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
|
r10 |
-0.142 |
-0.170 |
0.021 |
-0.584 |
-0.875 |
0.096 |
-0.020 |
0.476 |
-0.573 |
-0.021 |
|
r11 |
-0.006 |
-0.008 |
0.001 |
-0.027 |
-0.040 |
0.004 |
-0.001 |
0.022 |
-0.026 |
-0.001 |
|
r12 |
0.042 |
0.067 |
-0.007 |
0.173 |
0.275 |
-0.033 |
0.006 |
-0.163 |
0.169 |
-0.020 |
|
r13 |
-0.006 |
-0.010 |
0.001 |
-0.026 |
-0.041 |
0.005 |
-0.001 |
0.024 |
-0.026 |
0.003 |
|
r14 |
0.086 |
0.137 |
-0.014 |
0.352 |
0.561 |
-0.068 |
0.012 |
-0.331 |
0.345 |
-0.042 |
|
r15 |
-0.037 |
-0.059 |
0.006 |
-0.152 |
-0.242 |
0.029 |
-0.005 |
0.142 |
-0.149 |
0.017 |
|
r16 |
0.058 |
0.092 |
-0.009 |
0.237 |
0.377 |
-0.045 |
0.008 |
-0.222 |
0.233 |
-0.026 |
|
r17 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
|
r18 |
0.041 |
-0.632 |
-0.014 |
0.168 |
0.564 |
-0.050 |
0.006 |
-0.250 |
0.165 |
-0.130 |
|
r19 |
-0.168 |
0.594 |
0.006 |
-0.693 |
-0.261 |
0.162 |
-0.024 |
0.805 |
-0.679 |
0.264 |
|
r20 |
0.001 |
0.001 |
0.000 |
0.003 |
0.005 |
0.000 |
0.000 |
0.001 |
0.003 |
0.005 |
|
r21 |
0.000 |
0.000 |
0.000 |
-0.001 |
-0.001 |
0.000 |
0.000 |
0.001 |
-0.001 |
0.000 |
|
r22 |
0.016 |
-0.037 |
-0.001 |
0.066 |
0.044 |
0.005 |
0.002 |
0.020 |
0.065 |
0.091 |
|
r23 |
0.000 |
0.001 |
0.000 |
0.000 |
0.001 |
0.000 |
0.000 |
0.000 |
0.000 |
0.000 |
|
r24 |
-0.003 |
-0.005 |
0.000 |
-0.013 |
-0.020 |
0.002 |
0.000 |
0.012 |
-0.013 |
0.001 |
|
r25 |
0.000 |
0.004 |
0.000 |
-0.002 |
0.002 |
0.000 |
0.000 |
0.002 |
-0.002 |
0.000 |
|
r26 |
0.000 |
0.000 |
0.000 |
-0.001 |
-0.001 |
0.000 |
0.000 |
0.001 |
-0.001 |
0.000 |
|
r27 |
0.001 |
0.001 |
0.000 |
0.002 |
0.004 |
0.000 |
0.000 |
-0.002 |
0.002 |
0.001 |
|
r28 |
0.001 |
-0.009 |
0.000 |
0.002 |
-0.006 |
0.001 |
0.000 |
0.004 |
0.002 |
0.007 |
|
r29 |
0.004 |
-0.125 |
0.002 |
0.017 |
-0.101 |
0.010 |
0.001 |
0.050 |
0.017 |
0.077 |
|
r30 |
0.005 |
-0.005 |
0.000 |
0.019 |
0.018 |
-0.002 |
0.001 |
-0.012 |
0.019 |
0.005 |
|
r31 |
0.008 |
-0.008 |
-0.001 |
0.035 |
0.034 |
-0.004 |
0.001 |
-0.022 |
0.034 |
0.009 |
|
r32 |
0.005 |
-0.005 |
0.000 |
0.021 |
0.020 |
-0.003 |
0.001 |
-0.013 |
0.020 |
0.006 |
|
r33 |
0.005 |
-0.008 |
0.000 |
0.022 |
0.020 |
-0.002 |
0.001 |
-0.008 |
0.022 |
0.013 |
|
r34 |
0.005 |
-0.007 |
0.000 |
0.021 |
0.018 |
-0.002 |
0.001 |
-0.008 |
0.020 |
0.012 |
|
r35 |
0.001 |
-0.036 |
0.001 |
0.005 |
-0.029 |
0.003 |
0.000 |
0.014 |
0.005 |
0.022 |
|
r36 |
0.014 |
-0.429 |
0.008 |
0.058 |
-0.348 |
0.035 |
0.002 |
0.171 |
0.057 |
0.265 |
|
r37 |
0.001 |
-0.001 |
0.000 |
0.003 |
0.003 |
0.000 |
0.000 |
-0.001 |
0.003 |
0.001 |
|
r38 |
-0.002 |
0.026 |
0.000 |
-0.008 |
0.016 |
-0.001 |
0.000 |
-0.007 |
-0.008 |
-0.016 |
|
r39 |
-0.022 |
0.018 |
0.002 |
-0.092 |
-0.094 |
0.008 |
-0.003 |
0.039 |
-0.090 |
-0.046 |
|
r40 |
0.009 |
-0.012 |
-0.001 |
0.035 |
0.031 |
-0.003 |
0.001 |
-0.013 |
0.034 |
0.020 |
|
r41 |
-0.043 |
0.954 |
-0.017 |
-0.176 |
0.718 |
-0.105 |
-0.006 |
-0.523 |
-0.172 |
0.193 |
|
r42 |
-0.019 |
-0.028 |
0.003 |
-0.078 |
-0.122 |
0.011 |
-0.003 |
0.054 |
-0.076 |
-0.014 |
|
r43 |
0.033 |
0.016 |
-0.004 |
0.137 |
0.183 |
-0.016 |
0.005 |
-0.081 |
0.135 |
0.042 |
|
r44 |
-0.008 |
0.054 |
0.000 |
-0.034 |
0.012 |
0.003 |
-0.001 |
0.016 |
-0.033 |
-0.015 |
|
r45 |
0.001 |
-0.015 |
0.024 |
0.004 |
0.014 |
-0.001 |
0.000 |
-0.006 |
0.004 |
-0.003 |
|
r46 |
0.036 |
-0.480 |
0.007 |
0.148 |
-0.289 |
0.025 |
0.005 |
0.122 |
0.145 |
0.297 |
|
r47 |
0.002 |
0.007 |
0.000 |
0.010 |
0.019 |
-0.003 |
0.000 |
-0.013 |
0.009 |
-0.006 |
|
r48 |
0.004 |
0.007 |
-0.001 |
0.016 |
0.026 |
0.002 |
0.001 |
0.008 |
0.015 |
0.025 |
|
r49 |
0.003 |
-0.043 |
0.001 |
0.010 |
-0.030 |
0.003 |
0.000 |
0.016 |
0.010 |
0.030 |
|
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Partial flux control coefficients are only shown for metabolites having non-zero elasticities. The sum of the partial flux control coefficients for all intermediates equals the flux control coefficient. With regard to the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one. |
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Maier et al. BMC Systems Biology 2010 4:54 doi:10.1186/1752-0509-4-54 |
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