Table 4

Partial flux control coefficients for lactate dehydrogenase (r18) and oxidative phosphorylation (r41)

r18

r41


Partial flux control coefficient through

Partial flux control coefficient through



Enzyme

NADin

PYRin

LACin

NADHin

Flux control coefficient

ATPin

NADin

ADPin

NADHin

Flux control coefficient


r1

0.011

0.032

-0.002

0.043

0.084

-0.012

0.001

-0.060

0.042

-0.028

r2

0.009

0.014

-0.001

0.038

0.059

-0.007

0.001

-0.034

0.037

-0.003

r3

0.011

0.017

-0.002

0.044

0.071

-0.008

0.002

-0.041

0.044

-0.005

r4

0.014

0.022

-0.002

0.056

0.089

-0.011

0.002

-0.052

0.055

-0.006

r5

0.002

0.003

0.000

0.008

0.012

-0.001

0.000

-0.007

0.008

-0.001

r6

0.032

0.050

-0.005

0.132

0.209

-0.025

0.005

-0.124

0.129

-0.015

r7

0.000

0.001

0.000

0.002

0.003

0.000

0.000

-0.002

0.002

0.000

r8

0.000

0.012

0.000

-0.002

0.009

-0.001

0.000

-0.005

-0.002

-0.008

r9

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

r10

-0.142

-0.170

0.021

-0.584

-0.875

0.096

-0.020

0.476

-0.573

-0.021

r11

-0.006

-0.008

0.001

-0.027

-0.040

0.004

-0.001

0.022

-0.026

-0.001

r12

0.042

0.067

-0.007

0.173

0.275

-0.033

0.006

-0.163

0.169

-0.020

r13

-0.006

-0.010

0.001

-0.026

-0.041

0.005

-0.001

0.024

-0.026

0.003

r14

0.086

0.137

-0.014

0.352

0.561

-0.068

0.012

-0.331

0.345

-0.042

r15

-0.037

-0.059

0.006

-0.152

-0.242

0.029

-0.005

0.142

-0.149

0.017

r16

0.058

0.092

-0.009

0.237

0.377

-0.045

0.008

-0.222

0.233

-0.026

r17

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

r18

0.041

-0.632

-0.014

0.168

0.564

-0.050

0.006

-0.250

0.165

-0.130

r19

-0.168

0.594

0.006

-0.693

-0.261

0.162

-0.024

0.805

-0.679

0.264

r20

0.001

0.001

0.000

0.003

0.005

0.000

0.000

0.001

0.003

0.005

r21

0.000

0.000

0.000

-0.001

-0.001

0.000

0.000

0.001

-0.001

0.000

r22

0.016

-0.037

-0.001

0.066

0.044

0.005

0.002

0.020

0.065

0.091

r23

0.000

0.001

0.000

0.000

0.001

0.000

0.000

0.000

0.000

0.000

r24

-0.003

-0.005

0.000

-0.013

-0.020

0.002

0.000

0.012

-0.013

0.001

r25

0.000

0.004

0.000

-0.002

0.002

0.000

0.000

0.002

-0.002

0.000

r26

0.000

0.000

0.000

-0.001

-0.001

0.000

0.000

0.001

-0.001

0.000

r27

0.001

0.001

0.000

0.002

0.004

0.000

0.000

-0.002

0.002

0.001

r28

0.001

-0.009

0.000

0.002

-0.006

0.001

0.000

0.004

0.002

0.007

r29

0.004

-0.125

0.002

0.017

-0.101

0.010

0.001

0.050

0.017

0.077

r30

0.005

-0.005

0.000

0.019

0.018

-0.002

0.001

-0.012

0.019

0.005

r31

0.008

-0.008

-0.001

0.035

0.034

-0.004

0.001

-0.022

0.034

0.009

r32

0.005

-0.005

0.000

0.021

0.020

-0.003

0.001

-0.013

0.020

0.006

r33

0.005

-0.008

0.000

0.022

0.020

-0.002

0.001

-0.008

0.022

0.013

r34

0.005

-0.007

0.000

0.021

0.018

-0.002

0.001

-0.008

0.020

0.012

r35

0.001

-0.036

0.001

0.005

-0.029

0.003

0.000

0.014

0.005

0.022

r36

0.014

-0.429

0.008

0.058

-0.348

0.035

0.002

0.171

0.057

0.265

r37

0.001

-0.001

0.000

0.003

0.003

0.000

0.000

-0.001

0.003

0.001

r38

-0.002

0.026

0.000

-0.008

0.016

-0.001

0.000

-0.007

-0.008

-0.016

r39

-0.022

0.018

0.002

-0.092

-0.094

0.008

-0.003

0.039

-0.090

-0.046

r40

0.009

-0.012

-0.001

0.035

0.031

-0.003

0.001

-0.013

0.034

0.020

r41

-0.043

0.954

-0.017

-0.176

0.718

-0.105

-0.006

-0.523

-0.172

0.193

r42

-0.019

-0.028

0.003

-0.078

-0.122

0.011

-0.003

0.054

-0.076

-0.014

r43

0.033

0.016

-0.004

0.137

0.183

-0.016

0.005

-0.081

0.135

0.042

r44

-0.008

0.054

0.000

-0.034

0.012

0.003

-0.001

0.016

-0.033

-0.015

r45

0.001

-0.015

0.024

0.004

0.014

-0.001

0.000

-0.006

0.004

-0.003

r46

0.036

-0.480

0.007

0.148

-0.289

0.025

0.005

0.122

0.145

0.297

r47

0.002

0.007

0.000

0.010

0.019

-0.003

0.000

-0.013

0.009

-0.006

r48

0.004

0.007

-0.001

0.016

0.026

0.002

0.001

0.008

0.015

0.025

r49

0.003

-0.043

0.001

0.010

-0.030

0.003

0.000

0.016

0.010

0.030


Partial flux control coefficients are only shown for metabolites having non-zero elasticities. The sum of the partial flux control coefficients for all intermediates equals the flux control coefficient. With regard to the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one.

Maier et al. BMC Systems Biology 2010 4:54   doi:10.1186/1752-0509-4-54

Open Data