Additional file 4.

Partial internal response coefficients. According to the connectivity theorem, the sum of the partial internal response coefficients for each intermediate is -1. Perturbations in moiety-conserved sets cannot be counteracted in order to reach the previous steady state, which is the reason why no partial response coefficients are listed for ATP, ADP, AMP, NADP, NADPH, NAD, and NADH.

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Maier et al. BMC Systems Biology 2010 4:54   doi:10.1186/1752-0509-4-54