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Open Access Highly Accessed Research article

Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Klaus Maier1, Ute Hofmann2, Matthias Reuss1 and Klaus Mauch3*

Author Affiliations

1 Institute of Biochemical Engineering, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany

2 Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Auerbachstrasse 112, 70376 Stuttgart, Germany

3 Insilico Biotechnology AG, Nobelstrasse 15, 70569 Stuttgart, Germany

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BMC Systems Biology 2010, 4:54  doi:10.1186/1752-0509-4-54

Published: 28 April 2010

Additional files

Additional file 1:

Reference extracellular and intracellular metabolite levels. The subscripts 'ex' and 'in' denote extracellular and intracellular metabolites, respectively. Intracellular and extracellular values are given in mmol/lcv and mmol/lwell.

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Additional file 2:

Flux control coefficients

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Additional file 3:

Concentration control coefficients

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Additional file 4:

Partial internal response coefficients. According to the connectivity theorem, the sum of the partial internal response coefficients for each intermediate is -1. Perturbations in moiety-conserved sets cannot be counteracted in order to reach the previous steady state, which is the reason why no partial response coefficients are listed for ATP, ADP, AMP, NADP, NADPH, NAD, and NADH.

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Additional file 5:

Elasticity matrix. The scaled elasticities are based on metabolite time-series data. Only non-zero entries are shown. The subscript 'ex' denotes extracellular metabolites.

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