Figure 4.

Screenshots of the E. coli case-study: a) clipboard containing the original metabolic model, simplified model, simulation results and optimization results; b) view of the simulation results (objective function and net conversions) obtained for the wild-type strain; c) view of the simulation results (FBA) obtained for a mutant with enhanced capabilities regarding succinate production; d) view of the results obtained for the optimization using EAs and knockout list for the best solution found;