Table 7

GO term enrichments for central and terminal LCRs.

Terminal LCRs


Frequencies


Genes

Background

p-value

q-values

GO term ID

definition

22

147

1.09 × 10-10

2.76 × 10-08

(P)GO:0006950

response to stress

28

418

3.64 × 10-06

4.62 × 10-04

(P)GO:0006412

translation

6

15

8.55 × 10-06

7.24 × 10-04

(P)GO:0006414

translational elongation

5

10

2.19 × 10-05

0.001

(P)GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

5

26

8.99 × 10-04

0.046

(P)GO:0006893

Golgi to plasma membrane transport


13

114

1.37 × 10-05

0.002

(F)GO:0016887

ATPase activity

16

202

9.10 × 10-05

0.005

(F)GO:0003735

structural constituent of ribosome

5

33

0.002

0.087

(F)GO:0004175

endopeptidase activity

30

703

0.004

0.087

(F)GO:0000166

nucleotide binding

4

24

0.005

0.087

(F)GO:0005484

SNAP receptor activity

5

40

0.005

0.087

(F)GO:0003743

translation initiation factor activity

3

12

0.006

0.087

(F)GO:0003746

translation elongation factor activity

2

3

0.006

0.087

(F)GO:0019904

protein domain specific binding

7

85

0.008

0.092

(F)GO:0051082

unfolded protein binding

4

28

0.008

0.092

(F)GO:0003688

DNA replication origin binding

2

4

0.009

0.093

(F)GO:0008353

RNA polymerase subunit kinase activity

21

290

2.40 × 10-05

0.003

(C)GO:0005840

ribosome

5

14

7.83 × 10-05

0.006

(C)GO:0015935

small ribosomal subunit

19

284

1.63 × 10-04

0.008

(C)GO:0030529

ribonucleoprotein complex

6

43

0.001

0.038

(C)GO:0043234

protein complex

4

16

0.001

0.038

(C)GO:0000502

proteasome complex

3

9

0.003

0.051

(C)GO:0000786

nucleosome

3

9

0.003

0.051

(C)GO:0000788

nuclear nucleosome

3

9

0.003

0.051

(C)GO:0005852

eukaryotic translation initiation factor 3 complex

6

53

0.003

0.052

(C)GO:0022627

cytosolic small ribosomal subunit

3

10

0.004

0.052

(C)GO:0043614

multi-eIF complex

2

3

0.006

0.065

(C)GO:0034099

luminal surveillance complex

2

3

0.006

0.065

(C)GO:0030133

transport vesicle

2

3

0.006

0.065

(C)GO:0031201

SNARE complex

3

14

0.008

0.082

(C)GO:0005667

transcription factor complex

6

68

0.010

0.096

(C)GO:0030686

90S preribosome

11

189

0.011

0.098

(C)GO:0005730

nucleolus


Central LCRs


Frequencies


Genes

Background

p-value

q-value

GO term ID

definition


27

133

3.03 × 10-09

1.40 × 10-06

(P)GO:0006468

protein amino acid phosphorylation

50

518

4.38 × 10-06

0.001

(P)GO:0006350

transcription

45

490

4.52 × 10-05

0.007

(P)GO:0006355

regulation of transcription, DNA-dependent

7

18

9.81 × 10-05

0.011

(P)GO:0006378

mRNA polyadenylation

24

123

4.64 × 10-08

1.03 × 10-05

(F)GO:0004674

protein serine/threonine kinase activity

66

703

2.18 × 10-07

1.68 × 10-05

(F)GO:0000166

nucleotide binding

23

125

2.28 × 10-07

1.68 × 10-05

(F)GO:0004672

protein kinase activity

55

577

1.88 × 10-06

1.04 × 10-04

(F)GO:0005524

ATP binding

15

90

8.39 × 10-05

0.004

(F)GO:0004386

helicase activity

23

204

2.94 × 10-04

0.011

(F)GO:0016301

kinase activity

28

294

8.31 × 10-04

0.026

(F)GO:0003676

nucleic acid binding

10

61

0.001

0.036

(F)GO:0008026

ATP-dependent helicase activity

6

22

0.001

0.036

(F)GO:0004407

histone deacetylase activity

3

4

0.003

0.066

(F)GO:0004708

MAP kinase kinase activity

4

11

0.004

0.077

(F)GO:0005543

phospholipid binding

5

19

0.004

0.077

(F)GO:0016566

specific transcriptional repressor activity

15

63

2.04 × 10-06

3.39 × 10-04

(C)GO:0005934

cellular bud tip

132

1946

4.07 × 10-06

3.39 × 10-04

(C)GO:0005634

nucleus

26

189

5.24 × 10-06

3.39 × 10-04

(C)GO:0005730

nucleolus

5

9

2.89 × 10-04

0.014

(C)GO:0005849

mRNA cleavage factor complex

5

12

7.97 × 10-04

0.031

(C)GO:0000508

Rpd3L complex

16

129

9.96 × 10-04

0.032

(C)GO:0005935

cellular bud neck


GO term enrichments from proteins with c-LCRs and t-LCRs compared to the complete set of proteins in S. cerevisiae.

Coletta et al. BMC Systems Biology 2010 4:43   doi:10.1186/1752-0509-4-43

Open Data