Figure 11.

Simulated effect of TCDD in destabilizing the plasma cell state. (A) Bifurcation analysis in the absence of LPS indicates that as the concentration of TCDD increases, the plasma cell state (upper branch of the Blimp-1 vs. TCDD bifurcation diagram and lower branch of the Pax5 vs. TCDD bifurcation diagram) move closer to the intermediate unstable steady state (dashed branches), although they never coalesce. (B) Stochastic simulation using 10⁴ plasma cells demonstrated that TCDD destabilized the plasma cell state over time in a dose-dependent manner.