BMC Systems Biology

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Open Access Research article

Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

Qiang Zhang1*, Sudin Bhattacharya1, Douglas E Kline2, Robert B Crawford2, Rory B Conolly3, Russell S Thomas1, Norbert E Kaminski2 and Melvin E Andersen1

Author Affiliations

1 Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA

2 Department of Pharmacology & Toxicology and Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA

3 Integrated systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA

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BMC Systems Biology 2010, 4:40 doi:10.1186/1752-0509-4-40

Published: 1 April 2010

Additional files

Additional file 1:

Supplementary Materials. This file contains the ordinary differential equations, parameter values, and initial steady-state conditions for the B cell model presented in the main text, as well as additional figures from model simulations.

Format: PDF Size: 280KB Download file

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Open Data

Additional file 2:

B cell model in SBML format. This file is the SMBL version of the B cell model presented in the main text.

Format: XML Size: 18KB Download file

Open Data