Demonstration of a sample module found by the methods. (A) Shows a connected subgraph of the PPI network with 520 genes and 2633 protein interactions between them. Out of these, 99 genes belong to the Gene Ontology class Ribosome biogenesis (colored red in the graph) and form a clearly visible subgraph. Graphs (B-D) are subgraphs of (A), corresponding to a module found by methods ICMg2, HMoF and Matisse, respectively. Again, red color indicates that the gene belongs to the Ribosome biogenesis GO class.
Parkkinen and Kaski BMC Systems Biology 2010 4:4 doi:10.1186/1752-0509-4-4