Principal simulation scenarios considered in this study. (a) Scenarios (Sc.) 1-3: nuclear translocation of particles Ac (Sc. 1), followed by a unary reaction An → Bn (Sc. 2) and the translocation reaction competing with the unary reaction Ac → Bc (Sc. 3). (b) Sc. 4-5: nuclear translocation of Ac followed by a nuclear binary reaction An + Bn → Cn (Sc. 4) followed by the cytoplasmic translocation of the product Cn (Sc. 5). (c) Sc. 6: upon translocation molecules An and Dn compete for the same binding partner Bn (An + Bn → Cn and Dn + Bn → En) (d-e) Sc. 7-8: upon translocation molecules Ac are able to dimerize (Sc. 7) or bind to a species initially localized in the cell membrane (Sc. 8). (f) Sc. 9: upon translocation molecules Ac dimerize with molecules Bc and their product Cc is able to translocate back to the nucleus. In all corresponding temporal models of Sc.1-9, each delay distribution accounts for the spatial effects due to the diffusion of particles.
Marquez-Lago et al. BMC Systems Biology 2010 4:19 doi:10.1186/1752-0509-4-19