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Open Access Highly Accessed Research article

Statistical model comparison applied to common network motifs

Núria Domedel-Puig1*, Iosifina Pournara2 and Lorenz Wernisch3

Author Affiliations

1 Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Edifici GAIA, Rambla de Sant Nebridi s/n 08222, Terrassa, Barcelona, Spain

2 School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK

3 MRC Biostatistics Unit, Robinson Way, Cambridge CB2 0SR, UK

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BMC Systems Biology 2010, 4:18  doi:10.1186/1752-0509-4-18

Published: 3 March 2010

Additional files

Additional file 1:

Supplementary material for "Statistical model comparison applied to common network motifs". The example of estimating parameters for a simple DE model consisting of one equation is used to exemplify and discuss statistical issues of model selection as clearly as possible. Results for extended cooperativity effects in models SIM, RC, FF, and FB are also shown.

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