Table 5

Function of target genes of 9 miRNAs.

Gene Ontology (GO) category or pathway

Enrichment P-values


mir-15b

mir-15a

mir-16

mir-25

mir-106a

mir-93

mir-106b

mir-92

mir-323


Glioma

1.9E-02

Regulation of neurotransmitter levels

1.3E-02

1.1E-02

Neurotransmitter transport

6.8E-03

1.5E-02

3.3E-02

3.9E-02

Long-term potentiation

4.2E-03

3.7E-05

2.4E-03

3.1E-02

1.4E-02

5.3E-03

Synaptic transmission

2.4E-04

4.0E-04

5.3E-04

3.0E-06

4.4E-02

1.6E-03

Neurotransmitter secretion

1.7E-02

1.0E-02

2.9E-02

Nervous system development

3.2E-02

1.3E-02

5.5E-03

2.7E-02

Central nervous system development

2.5E-02

Transmission of nerve impulse

2.3E-04

9.6E-04

4.8E-04

1.8E-06

6.0E-04

Regulation of synaptic plasticity

4.6E-02

Synaptic vesicle transport

2.8E-02

3.1E-02

Regulation of synapse structure and activity

4.6E-02

Neurological system process

7.1E-03

4.3E-03

5.1E-03

1.5E-04

3.1E-03

Learning and/or memory

3.7E-02

Learning

4.0E-02

Neurofilament

2.1E-02

Synaptic vesicle

1.1E-02

8.0E-03

2.7E-02

Synaptosome

1.4E-02

Synaptic vesicle membrane

3.4E-02

Neuron projection

4.5E-02

Synapse part

4.7E-05

1.5E-02

2.5E-03

1.6E-02

1.2E-02

Synapse

4.9E-03

1.5E-02

2.1E-02

1.1E-07

6.2E-03

8.4E-04

5.3E-03

2.3E-04

Axon guidance

2.1E-02

Antigen processing and presentation

4.0E-02

Ras protein signal transduction

1.9E-02

2.3E-02

Calcium ion transport

1.8E-03

3.6E-04

7.8E-03

4.2E-02

Calcium signaling pathway

2.7E-04

7.5E-06

1.7E-03

1.7E-02

2.0E-04

2.2E-05

Cell communication

1.9E-02

2.2E-02

5.6E-03

2.3E-03

1.8E-02

2.6E-02

2.5E-02

Cell-cell signaling

1.4E-03

8.1E-04

9.5E-04

4.2E-06

7.0E-03

Wnt signaling pathway

4.0E-02

2.9E-03

7.6E-03

MAPK signaling pathway

1.5E-02

8.4E-03

3.8E-02

2.6E-02

GnRH signaling pathway

1.0E-02

8.7E-05

6.6E-03

ErbB signaling pathway

2.2E-02

3.0E-02

B cell receptor signaling pathway

6.3E-03

VEGF signaling pathway

8.4E-03

T cell receptor signaling pathway

2.1E-02

Apoptosis

2.1E-02


Dong et al. BMC Systems Biology 2010 4:163   doi:10.1186/1752-0509-4-163

Open Data