Table 3

13 Modules in gene coexpression network in Figure 2 with their enriched pathways.

Module

Module color

Pathway category

Name

P-value


1

Purple

Cell signaling

Ion channel and phorbal esters signaling

8.60E-03


2

Wind

stawberry

Apoptosis

Apoptotic DNA fragmentation and tissue homeostasis

3.52E-02

Cell cycle regulation

Activation of Src by protein-tyrosine phosphatase alpha

4.23E-02


Cell cycle regulation

AKAP95 role in mitosis and chromosome dynamics

4.98E-02


Cell cycle regulation

Sonic Hedgehog (SHH) Receptor Ptc1 regulates cell cycle

4.23E-02


3

Forest green

Translation

Ribosome

3.32E-09


4

Teal blue

Metabolism of cofactors and vitamins

One carbon pool by folate

4.72E-02


5

Black

Cell signaling

Ca++/Calmodulin-dependent protein kinase Activation

3.59E-03


6

Green

yellow

Immunology

Cells and molecules involved in local acute inflammatory response

4.68E-02


7

Yellow

Cell growth and death

Cell cycle

2.62E-02


8

Orange

Immunology

Classical complement

2.85E-02


9

Lavender

Cell signaling

IFN alpha signaling

1.03E-02


10

Blue

Cell activation

Th1/Th2 differentiation

3.79E-02


11

Olive green

Metabolism

Electron transport reaction in mitochondria

1.31E-02


Energy metabolism

Oxidative phosphorylation

9.00E-03


Neuro-degenerative diseases

Parkinson's disease

8.67E-03


12

Maroon

Translation

Ribosome

1.13E-03


13

Red

Metabolism/Neuroscience

Vitamin C in the brain

9.11E-03


Cell activation

Angiotensin-converting enzyme 2 regulates heart function

1.27E-02


Metabolism

Intrinsic prothrombin activation

3.83E-02


Metabolism

Platelet amyloid precursor protein

1.47E-02


Hematopoiesis

Regulators of bone mineralization

2.58E-03


Dong et al. BMC Systems Biology 2010 4:163   doi:10.1186/1752-0509-4-163

Open Data