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Open Access Highly Accessed Research article

Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma

Hua Dong12, Li Luo2, Shengjun Hong1, Hoicheong Siu1, Yanghua Xiao3, Li Jin1, Rui Chen4 and Momiao Xiong12*

Author Affiliations

1 State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China

2 Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA

3 Department of Computing and Information Technology, Shanghai (International) Database Research Center, Fudan University, Shanghai, 200433, China

4 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

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BMC Systems Biology 2010, 4:163  doi:10.1186/1752-0509-4-163

Published: 29 November 2010

Additional files

Additional file 1:

A list of 97 genes was differentially expressed which were previously reported to be involved in cancer.

Format: XLS Size: 28KB Download file

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Additional file 2:

The list of 1697 differentially expressed genes.

Format: XLS Size: 708KB Download file

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Additional file 3:

40 differentially expressed genes with damage values greater than 15.

Format: XLS Size: 23KB Download file

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Additional file 4:

A total of 149 differentially expressed miRNA.

Format: XLS Size: 56KB Download file

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Additional file 5:

Top 19 differentially expressed miRNAs with the largest damage values (> 20) in the miRNA coexpression network.

Format: XLS Size: 37KB Download file

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Additional file 6:

3,953 matched miRNA-mRNA pairs.

Format: XLS Size: 683KB Download file

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Additional file 7:

A total of 34 differentially expressed miRNA negatively regulates 17 genes with damage values greater than 19.

Format: XLS Size: 214KB Download file

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Additional file 8:

Target genes of top 19 miRNAs selected according to damage values of miRNA.

Format: XLS Size: 269KB Download file

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Additional file 9:

A total of 78 target genes with coefficient of determination greater than 20%.

Format: XLS Size: 40KB Download file

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Additional file 10:

177 significantly differentially expressed genes regulated by somatic mutation in 14 genes.

Format: XLS Size: 878KB Download file

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Additional file 11:

A total of 23 miRNAs were regulated by somatic mutations.

Format: XLS Size: 63KB Download file

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Additional file 12:

A total of 323 differentially expressed genes were regulated by LOH in the 11 genes associated with GBM.

Format: XLS Size: 84KB Download file

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Additional file 13:

A total of 19 miRNAs were regulated by LOH mutations.

Format: XLS Size: 22KB Download file

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Additional file 14:

Enriched GO and pathways targeted by Somatic and LOH mutation eQTL.

Format: XLS Size: 248KB Download file

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