Table 1

Significantly varying products upon EWS-FLI1 oncogene silencing

Node name

Variation

Node name

Variation

Node name

Variation


mRNA_RAS

+

mRNA_ECM1

+

mRNA_RBL2

-

mRNA_CCNE_

+

mRNA_ECM2

+

mRNA_SKP2

+

mRNA_NFKB_

+

mRNA_FAS

-

mRNA_SOS2

+

mRNA_PIK3C_

+

mRNA_FASLG

+

mRNA_TNFAIP3

+

mRNA_PIK3R_

-

mRNA_IER3

+

mRNA_TNFRSF1A

+


mRNA_RAC_

+

mRNA_IGF1

-

Phenotypic_observations


mRNA_RHO_

+

mRNA_IGFBP3

+

mRNA_TGFB_

+

mRNA_JUN

+

EWS-FLI1

-

mRNA_TNF_

+

mRNA_MAPK8

+

Cell_Cycle_Anaphase

-

mRNA_AKT1

+

mRNA_MYC

-

Cell_Cycle_G2

-

mRNA_CDKN1A

+

mRNA_MYCBP

-

Cell_Cycle_M

-

mRNA_CDKN1C

+

mRNA_PDGFRB

+

Cell_Cycle_S

-

mRNA_CYCS

-

mRNA_PRKCB1

-

Cell_Migration

-

mRNA_E2F5

-

mRNA_RASA1

+

Apoptosis

+


List of observations used as an input set for BioQuali. Table contains the list of significantly varying genes resulting from the analysis of microarray data [21]. The last seven lines of the third column contain additional variations on so-called 'phenotypical nodes' and on the EWS-FLI1 protein. They summarize the current literature-derived knowledge on cell behavior upon silencing EWS-FLI1 oncogene.

Baumuratova et al. BMC Systems Biology 2010 4:146   doi:10.1186/1752-0509-4-146

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