Inconsistencies in the original interaction graph. The inconsistencies indicate parts of the network where the original regulatory model fails to satisfy the generic biological rule of BioQuali. In part A, node (PIK3R.) has only one precursor, PDGFRB, and its variation (PDGFRB = '+') cannot explain the variation of (PIK3R.) ((PIK3R.) = '-'). In part B, the variation of the phenotypic node 'Cell Migration' ('Cell Migration' = '-') cannot be explained by either of the variations of its precursors: (RAC.) = '+' and (RHO.) = '+'.
Baumuratova et al. BMC Systems Biology 2010 4:146 doi:10.1186/1752-0509-4-146