Table 2

Metabolite exchanges between parasite and host: prediction vs. experiment

Metabolite

Predicted

Experiment

Comment

References


Glucose

Uptake

uptake

[57,128,129]

Lactate

Secretion

secretion

[57,128,129]

Hemoglobin

uptake

uptake

[57,128]

Amino acids

Secretion

secretion

[57,128,129]

Isoleucine

uptake

uptake

[57,128,129]

Nucleosides/nucleobases

uptake

uptake

[128-130]

Choline

uptake

uptake

[68,128,129,131]

Ethanolamine

almost no exchange

uptake

No gene assigned to ethanolamine transporter

[128,132]

Phosphatidylethanolamine

uptake

uptake

[128,132]

Phosphatidylserine

uptake

uptake

[128]

Phosphate

uptake

uptake

[64,128,129]

Pantothenate

uptake

uptake

[62,128,129]

Nicotinamide/nicotinate

uptake

uptake

[43,128]

Folate

uptake

uptake

[128,129]

4-aminobenzoic acid

uptake

uptake

[128,129]

ADP

uptake/secretion

uptake

secretion in early blood stage when ATP can still be salvaged from host

[65,128,129]

ATP

uptake/secretion

secretion

uptake in early blood stage when host glycolysis is not repressed yet

[65,128,129]

Glycerol

uptake/secretion

uptake/secretion

[128,129]

Glutathione conjugate

secretion

secretion

[63,128,129]

Ornithine

mostly secretion

secretion

[43]

Cholesterol

uptake

uptake

[128]

Formate

no exchange

secretion

Erythrocyte lacks reactions and transport processes to dispose of metabolite

[128,129]

Fe2+

no exchange/uptake

uptake

[128,129]

H+

Mostly secretion

secretion

[128,129]

HC03-

no exchange

secretion

Erythrocyte lacks reactions and transport processes to dispose of metabolite

[128,129]


Huthmacher et al. BMC Systems Biology 2010 4:120   doi:10.1186/1752-0509-4-120

Open Data