Additional file 5.

Bozdech gene expression samples mapped onto metabolic pathways. Mapping gene expression data onto metabolic networks may uncover active pathways for each stage and metabolic differences between the individual life cycle stages. For this purpose, we calculated the ratio of expressed genes per KEGG pathway (# expressed genes/# genes with available expression data for pathway) for each Bozdech gene expression sample. The darker the color of a matrix entry, the lower is the ratio. Clusters of pathways with similar patterns of expressed genes during the individual life cycle time points were calculated with the built-in function hclust ('average' method) of the statistics software R (colored bars).

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Huthmacher et al. BMC Systems Biology 2010 4:120   doi:10.1186/1752-0509-4-120