Additional file 10.

Normalized Hamming distance matrix for calculated flux distributions. Flux distributions have been predicted with our flux balance approach (see Figure 1) for each time point of the parasite's life cycle for which a gene expression profile exists. Simulations were conducted considering only the metabolic network of the parasite without any further constraints reflecting the parasite's environment and without considering the expression status of genes during preceding time points. In order to compare the individual flux distributions normalized Hamming distances (see text for formula) have been determined for all pairs of flux distributions. The darker the color of a matrix entry, the lower is the corresponding Hamming distance.

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Huthmacher et al. BMC Systems Biology 2010 4:120   doi:10.1186/1752-0509-4-120