Table 1 |
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|
Top 50 hub nodes in the InnateDB-curated human innate immunity interactome. |
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|
Gene |
InnateDB ID |
Ensembl ID |
Entrez ID |
Degree |
BottleNeck |
|
|
|||||
|
RELA |
IDBG-57543 |
ENSG00000173039 |
5970 |
104 |
* |
|
CTNNB1 |
IDBG-27347 |
ENSG00000168036 |
1499 |
92 |
* |
|
IRF1 |
IDBG-42125 |
ENSG00000125347 |
3659 |
92 |
* |
|
TRAF6 |
IDBG-40102 |
ENSG00000175104 |
7189 |
90 |
* |
|
STAT1 |
IDBG-77617 |
ENSG00000115415 |
6772 |
86 |
* |
|
AKT1 |
IDBG-22709 |
ENSG00000142208 |
207 |
81 |
* |
|
NFKB1 |
IDBG-31974 |
ENSG00000109320 |
4790 |
75 |
* |
|
IKBKB |
IDBG-19987 |
ENSG00000104365 |
3551 |
71 |
* |
|
EP300 |
IDBG-8992 |
ENSG00000100393 |
2033 |
70 |
* |
|
CHUK |
IDBG-243385 |
ENSG00000213341 |
1147 |
65 |
* |
|
IRAK1 |
IDBG-90782 |
ENSG00000184216 |
3654 |
55 |
* |
|
MAPK1 |
IDBG-2147 |
ENSG00000100030 |
5594 |
54 |
* |
|
IRF3 |
IDBG-63225 |
ENSG00000126456 |
3661 |
51 |
|
|
MAP3K7 |
IDBG-94374 |
ENSG00000135341 |
6885 |
50 |
* |
|
TRAF2 |
IDBG-92817 |
ENSG00000127191 |
7186 |
49 |
* |
|
ERBB2IP |
IDBG-24405 |
ENSG00000112851 |
55914 |
48 |
* |
|
SNTA1 |
IDBG-66573 |
ENSG00000101400 |
6640 |
48 |
* |
|
SQSTM1 |
IDBG-61811 |
ENSG00000161011 |
8878 |
47 |
* |
|
STAT3 |
IDBG-50702 |
ENSG00000168610 |
6774 |
46 |
* |
|
IKBKG |
IDBG-91846 |
ENSG00000073009 |
8517 |
45 |
* |
|
REL |
IDBG-53133 |
ENSG00000162924 |
5966 |
45 |
|
|
NFKBIA |
IDBG-4758 |
ENSG00000100906 |
4792 |
44 |
* |
|
IRF2 |
IDBG-46310 |
ENSG00000168310 |
3660 |
42 |
|
|
CASP3 |
IDBG-46394 |
ENSG00000164305 |
836 |
41 |
* |
|
PRKCZ |
IDBG-86108 |
ENSG00000067606 |
5590 |
41 |
* |
|
BIRC3 |
IDBG-69045 |
ENSG00000023445 |
330 |
40 |
* |
|
IRF4 |
IDBG-55681 |
ENSG00000137265 |
3662 |
40 |
* |
|
IRF8 |
IDBG-45278 |
ENSG00000140968 |
3394 |
40 |
* |
|
MAPK8 |
IDBG-73479 |
ENSG00000107643 |
5599 |
40 |
* |
|
MTOR |
IDBG-89258 |
ENSG00000198793 |
2475 |
40 |
* |
|
CASP8 |
IDBG-78534 |
ENSG00000064012 |
841 |
38 |
* |
|
IL8 |
IDBG-23954 |
ENSG00000169429 |
3576 |
38 |
* |
|
IRF7 |
IDBG-17225 |
ENSG00000185507 |
3665 |
38 |
|
|
JUN |
IDBG-99221 |
ENSG00000177606 |
3725 |
38 |
* |
|
MAPK14 |
IDBG-84613 |
ENSG00000112062 |
1432 |
38 |
* |
|
XIAP |
IDBG-85142 |
ENSG00000101966 |
331 |
38 |
* |
|
MAVS |
IDBG-49080 |
ENSG00000088888 |
57506 |
36 |
* |
|
IKBKAP |
IDBG-79889 |
ENSG00000070061 |
8518 |
35 |
* |
|
TSC1 |
IDBG-90470 |
ENSG00000165699 |
7248 |
35 |
* |
|
BIRC2 |
IDBG-69075 |
ENSG00000110330 |
329 |
34 |
|
|
RAF1 |
IDBG-19277 |
ENSG00000132155 |
5894 |
34 |
* |
|
CUL1 |
IDBG-46918 |
ENSG00000055130 |
8454 |
33 |
* |
|
HRAS |
IDBG-16878 |
ENSG00000174775 |
3265 |
33 |
* |
|
RIPK1 |
IDBG-57326 |
ENSG00000137275 |
8737 |
33 |
* |
|
GZMB |
IDBG-4054 |
ENSG00000100453 |
3002 |
32 |
* |
|
NFKB2 |
IDBG-87893 |
ENSG00000077150 |
4791 |
32 |
|
|
PIK3R1 |
IDBG-25037 |
ENSG00000145675 |
5295 |
32 |
* |
|
MAPK3 |
IDBG-25745 |
ENSG00000102882 |
5595 |
31 |
|
|
MYD88 |
IDBG-25713 |
ENSG00000172936 |
4615 |
31 |
|
|
PAK1 |
IDBG-65610 |
ENSG00000149269 |
5058 |
31 |
|
|
|
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|
Lynn et al. BMC Systems Biology 2010 4:117 doi:10.1186/1752-0509-4-117 |
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