Table 1

Top 50 hub nodes in the InnateDB-curated human innate immunity interactome.

Gene

InnateDB ID

Ensembl ID

Entrez ID

Degree

BottleNeck


RELA

IDBG-57543

ENSG00000173039

5970

104

*

CTNNB1

IDBG-27347

ENSG00000168036

1499

92

*

IRF1

IDBG-42125

ENSG00000125347

3659

92

*

TRAF6

IDBG-40102

ENSG00000175104

7189

90

*

STAT1

IDBG-77617

ENSG00000115415

6772

86

*

AKT1

IDBG-22709

ENSG00000142208

207

81

*

NFKB1

IDBG-31974

ENSG00000109320

4790

75

*

IKBKB

IDBG-19987

ENSG00000104365

3551

71

*

EP300

IDBG-8992

ENSG00000100393

2033

70

*

CHUK

IDBG-243385

ENSG00000213341

1147

65

*

IRAK1

IDBG-90782

ENSG00000184216

3654

55

*

MAPK1

IDBG-2147

ENSG00000100030

5594

54

*

IRF3

IDBG-63225

ENSG00000126456

3661

51

MAP3K7

IDBG-94374

ENSG00000135341

6885

50

*

TRAF2

IDBG-92817

ENSG00000127191

7186

49

*

ERBB2IP

IDBG-24405

ENSG00000112851

55914

48

*

SNTA1

IDBG-66573

ENSG00000101400

6640

48

*

SQSTM1

IDBG-61811

ENSG00000161011

8878

47

*

STAT3

IDBG-50702

ENSG00000168610

6774

46

*

IKBKG

IDBG-91846

ENSG00000073009

8517

45

*

REL

IDBG-53133

ENSG00000162924

5966

45

NFKBIA

IDBG-4758

ENSG00000100906

4792

44

*

IRF2

IDBG-46310

ENSG00000168310

3660

42

CASP3

IDBG-46394

ENSG00000164305

836

41

*

PRKCZ

IDBG-86108

ENSG00000067606

5590

41

*

BIRC3

IDBG-69045

ENSG00000023445

330

40

*

IRF4

IDBG-55681

ENSG00000137265

3662

40

*

IRF8

IDBG-45278

ENSG00000140968

3394

40

*

MAPK8

IDBG-73479

ENSG00000107643

5599

40

*

MTOR

IDBG-89258

ENSG00000198793

2475

40

*

CASP8

IDBG-78534

ENSG00000064012

841

38

*

IL8

IDBG-23954

ENSG00000169429

3576

38

*

IRF7

IDBG-17225

ENSG00000185507

3665

38

JUN

IDBG-99221

ENSG00000177606

3725

38

*

MAPK14

IDBG-84613

ENSG00000112062

1432

38

*

XIAP

IDBG-85142

ENSG00000101966

331

38

*

MAVS

IDBG-49080

ENSG00000088888

57506

36

*

IKBKAP

IDBG-79889

ENSG00000070061

8518

35

*

TSC1

IDBG-90470

ENSG00000165699

7248

35

*

BIRC2

IDBG-69075

ENSG00000110330

329

34

RAF1

IDBG-19277

ENSG00000132155

5894

34

*

CUL1

IDBG-46918

ENSG00000055130

8454

33

*

HRAS

IDBG-16878

ENSG00000174775

3265

33

*

RIPK1

IDBG-57326

ENSG00000137275

8737

33

*

GZMB

IDBG-4054

ENSG00000100453

3002

32

*

NFKB2

IDBG-87893

ENSG00000077150

4791

32

PIK3R1

IDBG-25037

ENSG00000145675

5295

32

*

MAPK3

IDBG-25745

ENSG00000102882

5595

31

MYD88

IDBG-25713

ENSG00000172936

4615

31

PAK1

IDBG-65610

ENSG00000149269

5058

31


Lynn et al. BMC Systems Biology 2010 4:117   doi:10.1186/1752-0509-4-117

Open Data