Table 4

Pathways enriched among the targets of 3 core miRNAs

miRNA

Enriched pathway of miRNA targetsa

p-value


hsa-miR-195

TGF-β signaling

3.98 × 10-5

Axonal guidance signaling

1.35 × 10-4

Wnt/β-catenin signaling

2.04 × 10-4

BMP signaling pathway

3.47 × 10-4

FGF signaling

7.59 × 10-4

Protein ubiquitination pathway

9.12 × 10-4

CDK5 signaling

1.55 × 10-3

PTEN signaling

1.86 × 10-3

Amyloid processing

2.00 × 10-3

B cell receptor signaling

3.72 × 10-3

Inositol phosphate metabolism

4.57 × 10-3

PI3K/AKT signaling

4.79 × 10-3

Reelin signaling in neurons

4.79 × 10-3

Synaptic long term potentiation

7.08 × 10-3

PPARα/RXRα activation

7.59 × 10-3

Ephrin receptor signaling

7.59 × 10-3

Insulin receptor signaling

9.12 × 10-3

hsa-miR-20b

Cell cycle: G1/S checkpoint regulation

1.10 × 10-4

Reelin signaling in neurons

2.75 × 10-4

B cell receptor signaling

3.55 × 10-4

Axonal guidance signaling

4.17 × 10-4

TGF-β signaling

5.50 × 10-4

p53 signaling

1.12 × 10-3

Semaphorin signaling in neurons

1.29 × 10-3

SAPK/JNK signaling

1.35 × 10-3

Hypoxia signaling in the cardiovascular system

2.04 × 10-3

Wnt/β-catenin signaling

3.24 × 10-3

PI3K/AKT signaling

3.89 × 10-3

CNTF signaling

3.98 × 10-3

Cell cycle: G2/M DNA damage checkpoint regulation

5.75 × 10-3

Circadian rhythm signaling

6.03 × 10-3

Ephrin receptor signaling

6.03 × 10-3

Factors promoting cardiogenesis in vertebrates

7.41 × 10-3

FGF signaling

7.41 × 10-3

HIF1α signaling

7.59 × 10-3

ERK/MAPK signaling

8.71 × 10-3

hsa-miR-9-3

ERK/MAPK signaling

1.58 × 10-4

Regulation of actin-based motility by Rho

2.88 × 10-3

Clathrin-mediated endocytosis

3.72 × 10-3

Axonal guidance signaling

3.89 × 10-3

Ephrin receptor signaling

4.17 × 10-3

Fcγ receptor-mediated phagocytosis in macrophages and monocytes

6.31 × 10-3


aPathways in italic are related to nervous system or schizophrenia.

Guo et al. BMC Systems Biology 2010 4:10   doi:10.1186/1752-0509-4-10

Open Data