Research article
The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis
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* Corresponding author: Teresa M Przytycka przytyck@ncbi.nlm.nih.gov
- † Equal contributors
1 National Cancer Institute National Institutes of Health Bethesda MD, USA
2 Columbia College Columbia University New York, NY, USA
3 National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Bethesda, MD, USA
4 Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA
BMC Systems Biology 2009, 3:88 doi:10.1186/1752-0509-3-88
Published: 4 September 2009Additional files
Additional file 1:
Phosphorylation level of receptors following stimulations with respective ligands in SKOV3 cells. Estimation of receptor phsosporylation as the function of ligand concentration. Estimation of Cross-stimulation of IGF-1R and IR
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Additional file 2:
Phosphorylation of Erk1/2, Jnk, Akt1, P70S6K following stimulation and co-stimulation of EGFR, IGF-1R, and IR. Tables of phosphorylation levels of four "output" protein in response to 25%- wise increase of receptor saturation along with simulation- predicted values.
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