Table 1

List of genes used in this analysis.

Name

Protein name

Protein class

Main function


COL1A1

Type I collagen alpha 1 chain

Structural component

Cartilage and connective tissue collagen

COL1A2

Type I collagen alpha 2 chain

Structural component

Cartilage and connective tissue collagen

MMP1

Matrix metalloprotease 1 (interstitial collagenase)

Protease

Cleavage of collagen I, II, and III

MMP3

Matrix metalloprotease 3 (stromelysin 1)

Protease

ECM component degradation

MMP9

Matrix metalloprotease 9 (gelatinase B)

Protease

Cleavage of collagen IV and V

MMP13

Matrix metalloprotease 13 (collagenase 3)

Protease

Cleavage of collagen I and III

TIMP1

Tissue inhibitor of metalloprotease 1 (collagenase inhibitor)

Protease inhibitor

Inhibits matrix metalloproteases, and others

ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1

Transcription factor

Erythroblast and fibroblast transformation

FOS

v-fos FBJ murine osteosarcoma viral oncogene homolog

Component of AP-1

Regulator of proliferation, differentiation, and transformation

JUN

v-jun avian sarcoma virus 17 oncogene homolog

Component of AP-1

Regulator of proliferation, differentiation, and transformation

JUNB

jun B proto-oncogene

Component of AP-1

Regulator of proliferation, differentiation, and transformation

JUND

jun D proto-oncogene

Component of AP-1

Regulator of proliferation, differentiation, and transformation

NKFB1

Subunit 1 of nuclear factor kappa-B

Component of NF-κB

Involved in many biological processes

SMAD3

SMA- and MAD-related protein 3

Transcriptional modulator

Mediator of signal transduction by TGFβ1 (RSMAD)

SMAD4

SMA- and MAD-related protein 4

Transcriptional modulator

Mediator of signal transduction by TGFβ1 (CoSMAD)

SMAD7

SMA- and MAD-related protein 7

Transcriptional modulator

Antagonist of signalling by TGFβ1 (ISMAD)

TNF

Tumour necrosis factor alpha

Cytokine

Proinflammatory role

TGFB1

Transforming growth factor beta 1

Growth factor

Involved in proliferation and differentiation


Wollbold et al. BMC Systems Biology 2009 3:77   doi:10.1186/1752-0509-3-77

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