Table 2

List of transcription factors that are known to interact synergistically with SMAD (collected from literature search)

Cofactors

Target genes


GATA4

IAP, IFABP [74]; INHA [75]


C/EBPβ, E2F4/5, FoxO

p15INK4b [76]; c-MYC, p21Cip1, GADD45A, GADD45B, IER1, CTGF, JAG1, LEMD3, SGK, CDC42EP3, and OVOL1 [77]


STAT3

GFAP; HP [78-80]


LEF/TCF

MYC [81]; Xtwn [52]


TCF/β-catenin, AP1

Gastrin [82,83]


MYOCD

SM22alpha, Tagln [84]


P53

AFP [85], AFP [56]


SOX9

COL2A1[86]


COUPTF

COL7A1[54].


SP1, SP3

LPL [87]; vimentin [88]


ETS-1

CCN2 [89]


NFKappaB and AP1

IL6 [90]


HIF1α

VEGF [91]


AP-1

ET1 [92]


HNF-4

apolipoprotein C-III [58]


TFE-3

SERPINE1 (PAI-1) [93]


MITF

mmcp-7 [94]


OCT-1

GATA2 [95,9]


AP-2

Col7a1[7]


RARγ

human gene promoter construct [59]


Qin et al. BMC Systems Biology 2009 3:73   doi:10.1186/1752-0509-3-73

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