Ingenuity Pathway Analysis of SMAD targets: (A) A graphical representation of overlapping signaling pathways detected in differentially expressed genes and SMAD-target genes. Wnt/β-catenin was found to be significant. (B) The result of Ingenuity analyses of Affymerix gene expression and SMAD-predicted datasets. There are total nine significant signaling pathways (shown in bar graphs) for gene expression data, and six significant signaling pathways for SMAD-predicted molecules (shown by asterisks). There is a major functional overlap (about 70% or 6/9) between gene expression and SMAD-predicted data. Note that the p values were calculated by Ingenuity algorithm http://www.ingenuity.com webcite per each pathway within Affymerix gene expression dataset and minus log p values are shown. The minus log p values for SMAD-predicted molecules are not shown.
Qin et al. BMC Systems Biology 2009 3:73 doi:10.1186/1752-0509-3-73