Research article
Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach
-
* Corresponding authors: Johannes Witt witt@isys.uni-stuttgart.de - Dagmar Kulms dagmar.kulms@izi.uni-stuttgart.de
- † Equal contributors
1 Institute for System Dynamics, Universität Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany
2 Institute of Cell Biology and Immunology, Universität Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
3 Institute for Systems Theory and Automatic Control, Universität Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany
4 Life Sciences Research Unit, University of Luxembourg, 162 A, avenue de la Faïencerie, 1511 Luxembourg, Luxembourg
BMC Systems Biology 2009, 3:71 doi:10.1186/1752-0509-3-71
Published: 16 July 2009Additional files
Additional file 1:
Supplementary information about the modelling procedure. Includes a more detailed description of several aspects of the modelling procedure.
Format: PDF Size: 155KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
Simulation results of the reference model with different parameterization. The fit is slightly worse but visually more satisfactory than the reference scenario.
Format: PDF Size: 67KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 3:
Simulation results for the alternative model with delayed PP2A activation. Shows the fit and describes the model equations of the alternative model.
Format: PDF Size: 82KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 4:
Representative Western Blot Analysis. Representative Western Blot of PP2Ac-dependent IKKβ phosphorylation
Format: PDF Size: 116KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 5:
Simulation results for IL-1 receptor internalisation. Shows the amount of total IL-1 receptor (ILR + ILRc) in the reference scenario.
Format: PDF Size: 17KB Download file
This file can be viewed with: Adobe Acrobat Reader