Schematic representation of the in silico strategy used to decipher a N/hormone crosstalk module. (A) The strategy was to discover via sequential biclustering filtering stages, co-regulated genes in response to: i) N treatments, and also ii) hormone treatments. (B) This delimitation of gene groups (whole genome, NO3--regulated, Bicluster9 NO3--regulated and NO3-/hormone co-regulated) and the comparison of their behavior allowed us to hypothesize how NO3- and hormonal signaling pathways are connected in gene networks.
Nero et al. BMC Systems Biology 2009 3:59 doi:10.1186/1752-0509-3-59