Table 2 |
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|
Top pathways enriched using genetic association research or environmental factor research. |
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|
Top 15 pathways enriched using phenotype-gene research compiled in the Genetic Association Database |
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|
Pathway Name |
KEGG pathway ID |
Number of diseases significantly enriched for pathway |
Number of environmental factors significantly enriched for pathway |
|
|
|||
|
Antigen processing and presentation |
path:hsa04612 |
59 |
57 |
|
Metabolism of xenobiotics by cytochrome P450 |
path:hsa00980 |
49 |
421 |
|
Hematopoietic cell lineage |
path:hsa04640 |
40 |
52 |
|
Renin-angiotensin system |
path:hsa04614 |
28 |
29 |
|
Retinol metabolism |
path:hsa00830 |
27 |
659 |
|
Natural killer cell mediated cytotoxicity |
path:hsa04650 |
26 |
97 |
|
Neuroactive ligand-receptor interaction |
path:hsa04080 |
24 |
30 |
|
Tyrosine metabolism |
path:hsa00350 |
23 |
28 |
|
Jak-STAT signaling pathway |
path:hsa04630 |
20 |
104 |
|
Complement and coagulation cascades |
path:hsa04610 |
16 |
24 |
|
Linoleic acid metabolism |
path:hsa00591 |
15 |
97 |
|
Cytokine-cytokine receptor interaction |
path:hsa04060 |
15 |
63 |
|
Adipocytokine signaling pathway |
path:hsa04920 |
15 |
185 |
|
T cell receptor signaling pathway |
path:hsa04660 |
13 |
38 |
|
Toll-like receptor signaling pathway |
path:hsa04620 |
12 |
114 |
|
Top 15 pathways enriched using environmental factor-gene research compiled in the Comparative Toxicogenomics Database |
|||
|
Pathway Name |
KEGG pathway ID |
Number of diseases significantly enriched for pathway |
Number of environmental factors significantly enriched for pathway |
|
|
|||
|
Retinol metabolism |
path:hsa00830 |
27 |
659 |
|
Apoptosis |
path:hsa04210 |
11 |
457 |
|
Metabolism of xenobiotics by cytochrome P450 |
path:hsa00980 |
49 |
421 |
|
gamma-Hexachlorocyclohexane degradation |
path:hsa00361 |
7 |
224 |
|
Androgen and estrogen metabolism |
path:hsa00150 |
5 |
194 |
|
PPAR signaling pathway |
path:hsa03320 |
11 |
189 |
|
Adipocytokine signaling pathway |
path:hsa04920 |
15 |
185 |
|
p53 signaling pathway |
path:hsa04115 |
7 |
160 |
|
Toll-like receptor signaling pathway |
path:hsa04620 |
12 |
114 |
|
Focal adhesion |
path:hsa04510 |
5 |
114 |
|
Cell cycle |
path:hsa04110 |
2 |
113 |
|
Pentose and glucuronate interconversions |
path:hsa00040 |
2 |
106 |
|
Jak-STAT signaling pathway |
path:hsa04630 |
20 |
104 |
|
Fc epsilon RI signaling pathway |
path:hsa04664 |
6 |
104 |
|
GnRH signaling pathway |
path:hsa04912 |
1 |
100 |
|
|
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|
Gohlke et al. BMC Systems Biology 2009 3:46 doi:10.1186/1752-0509-3-46 |
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