Pathway Interaction Network. Nodes represent KEGG metabolic and signaling pathways and are connected based on the KEGG database . Node size is reflective of the number of phenotypes associated with the particular pathway based on application of SEPEA (p ≤ 0.003) to gene lists annotated from The Genetic Association Database. Intensity of node color is reflective of the number of environmental factors associated with the particular pathway based on enrichment of gene lists annotated from The Comparative Toxicogenomics Database.
Gohlke et al. BMC Systems Biology 2009 3:46 doi:10.1186/1752-0509-3-46