Gene expression regulation across microarray datasets. Enriched transcription factor binding sites (tfbs) were identified in evolutionarily conserved regions surrounding differentially up and downregulated genes from metabolic (A.) or neuropsychiatric (B.) microarray datasets identified in Table 1 (see Methods). Results for each microarray dataset are presented in Additional file 4. The mean frequency of identifying a particular tfbs enriched in a dataset was 13% (dotted line). Those enriched tfbs that are consistently identified across the metabolic (A.) or neuropsychiatric (B.) datasets are color coded red (p ≤ 0.005), whereas those tfbs that are specific to the metabolic datasets versus neuropsychiatric datasets and vice versa (p ≤ 0.05) are identified with an asterisk.
Gohlke et al. BMC Systems Biology 2009 3:46 doi:10.1186/1752-0509-3-46