Figure 1.

Unsupervised Hierarchical Cluster of Phenotypes by Pathways. Genes associated with a particular phenotype were evaluated for enrichment in KEGG pathways using SEPEA. P-values for KEGG pathway enrichment were then clustered using Spearman rank correlation in Cluster and the graphic was prepared using TreeView [73], where color ranges linearly from blue (p = 1) to orange (p = 0). Phenotype-gene relationships were downloaded from the Genetic Association Database [1] in June 2007 and phenotypes were further grouped according to Additional file 1. Request the TreeView file of this cluster from Julia Gohlke for more detailed exploration.

Gohlke et al. BMC Systems Biology 2009 3:46   doi:10.1186/1752-0509-3-46
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