Clustergram of top reporter metabolites (i.e. in yellow) in ammonium-toxic and potassium-limited conditions. Amino acid perturbation patterns (shown in red) were shown to be consistently scored across conditions, indicating that potassium-limited environments K1 (lowest concentration) and K2 (low concentration) elicited a similar ammonium detoxification response as ammonium-toxic environments N1 (high concentration) and N2 (highest concentration). Metabolites associated with folate metabolism (highlighted in green) are also highly perturbed in ammonium-toxic conditions. Metabolite abbreviations are found in Additional file 1.
Mo et al. BMC Systems Biology 2009 3:37 doi:10.1186/1752-0509-3-37