|
Ratios of simulated acyl-CoA concentrations before and after fasting |
|||
| 20% |
30% |
40% |
|
|
|
|||
| Control C8-ratio |
1.10 |
1.15 |
1.19 |
|
|
|||
| SCADD C4-ratio |
1.28 |
1.44 |
1.62 |
|
|
|||
| MCADD C8-ratio |
2.08 |
3.59 |
6.97 |
|
|
|||
| LCADD C14-ratio |
2.29 |
2.89 |
3.46 |
|
|
|||
| VLCADD C14-ratio |
1.16 |
1.25 |
1.33 |
|
Ratios of simulated acyl-CoA concentrations before and 30 days after 20%, 30%, and 40% increase of palmitoyl-CoA (C16). Note that the time to attain the steady-state increases with higher increase of C16 and is in case of LCADD higher than 30 days for 30% and 40% increase of C16 resulting in lower ratios (2.89 and 3.46) than the ratios calculated for MCADD (3.59 and 6.97). | |||
Modre-Osprian et al. BMC Systems Biology 2009 3:2 doi:10.1186/1752-0509-3-2 |
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