Table 1

ISEA CELL axioms

Axiom

Precondition*

Action

References


1

CELLS only

DIE and leave behind a LUMINAL SPACE

[3,5,51,52]


2

LUMINAL SPACE only

DIE and leave behind a LUMINAL SPACE

[3,5,51,52]


3

MATRIX only

DIVIDE; the daughter CELL replaces a randomly selected MATRIX

[3,22,53]


4

1 CELL and LUMINAL SPACES; no MATRIX

Produce and deposit MATRIX between self and the adjoining CELL

[21,54]


5

≥2 CELLS and LUMINAL SPACE; no MATRIX

DIE and leave behind a LUMINAL SPACE

[19,20,51]


6

≥1 CELL and MATRIX; no LUMINAL SPACE

DIVIDE; the daughter CELL replaces MATRIX that maximizes its number of CELL neighbors

[23,53,54]


7

MATRIX and ≥2 LUMINAL SPACES; no CELLS

DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX

[2,23]


8

CELLS, MATRIX, and ≥2 adjacent LUMINAL SPACES

DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX and LUMINAL SPACE

[2,23]


9

2 CELLS, MATRIX, and LUMINAL SPACE; POLARIZING condition

POLARIZE

[2,5]


10

DEPOLARIZING condition

DEPOLARIZE

[2,5]


11

All other configurations

Do nothing

[2]


12

POLARIZING condition; 1 MATRIX

Move and replace the neighboring MATRIX; leave behind a LUMINAL SPACE

[2,5]


* The precondition for each axiomatic operating principle (Fig. 1) takes into consideration the six objects adjacent to the decision-making CELL. Two CELL neighbors separate MATRIX on one side from LUMINAL SPACE on the other side. A POLARIZED CELL has noncontiguous MATRIX neighbors.

Kim et al. BMC Systems Biology 2009 3:122   doi:10.1186/1752-0509-3-122

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