Table 1 

ISEA CELL axioms 

Axiom 
Precondition* 
Action 
References 


1 
CELLS only 
DIE and leave behind a LUMINAL SPACE 



2 
LUMINAL SPACE only 
DIE and leave behind a LUMINAL SPACE 



3 
MATRIX only 
DIVIDE; the daughter CELL replaces a randomly selected MATRIX 



4 
1 CELL and LUMINAL SPACES; no MATRIX 
Produce and deposit MATRIX between self and the adjoining CELL 



5 
≥2 CELLS and LUMINAL SPACE; no MATRIX 
DIE and leave behind a LUMINAL SPACE 



6 
≥1 CELL and MATRIX; no LUMINAL SPACE 
DIVIDE; the daughter CELL replaces MATRIX that maximizes its number of CELL neighbors 



7 
MATRIX and ≥2 LUMINAL SPACES; no CELLS 
DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX 



8 
CELLS, MATRIX, and ≥2 adjacent LUMINAL SPACES 
DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX and LUMINAL SPACE 



9 
2 CELLS, MATRIX, and LUMINAL SPACE; POLARIZING condition^{†} 
POLARIZE 



10 
DEPOLARIZING condition^{‡} 
DEPOLARIZE 



11 
All other configurations 
Do nothing 
[2] 


12 
POLARIZING condition; 1 MATRIX 
Move and replace the neighboring MATRIX; leave behind a LUMINAL SPACE 



* The precondition for each axiomatic operating principle (Fig. 1) takes into consideration the six objects adjacent to the decisionmaking CELL. ^{† }Two CELL neighbors separate MATRIX on one side from LUMINAL SPACE on the other side. ^{‡ }A POLARIZED CELL has noncontiguous MATRIX neighbors. 

Kim et al. BMC Systems Biology 2009 3:122 doi:10.1186/175205093122 