Simultaneous dysregulation of Axioms 5 and 6 and its effect on ISEA CULTURE growth and morphology. Axioms 5 and 6 dictate ANOIKIS (a form of CELL DEATH) and oriented CELL DIVISION; both are essential to normal CYST growth in EMBEDDED CULTURE. With a parameter-controlled probability, p, for each of the two axioms, CELLS followed an alternate, dysregulated action. For Axiom 5, the alternate action was to evade ANOIKIS (i.e., do nothing). For Axiom 6, it was disoriented CELL DIVISION; the CELL copy replaces a randomly selected matrix neighbor. The lower case letters (a-i) in (A) and (B) correspond to the morphologies in (C). (A) ISEA CELL population, (B) morphology index values, and (C) simulation images after 50 simulation cycles of growth. One simulation cycle maps to 12 h in vitro. Each object is represented as a hexagon: POLARIZED CELL (red), UNPOLARIZED CELL (gray), MATRIX (white), and LUMINAL SPACE (black). One CELL width maps to 10 μm. The CELL count and morphology measurements are mean values of 100 Monte Carlo runs.
Kim et al. BMC Systems Biology 2009 3:122 doi:10.1186/1752-0509-3-122