The twelve ISEA axiomatic operating principles. Table 1 is a listing and explanation of the operating principles. The 2D space and all objects within are hexagonally discretized. Simulation time advances in steps corresponding to simulation cycles. During a simulation cycle, every CELL, in a pseudo-random order, decides what action to take based on its internal state (POLARIZED or UNPOLARIZED) and the composition of its adjacent neighborhood. A set of axioms determines what action is taken for each possible neighborhood configurations. Objects represented: POLARIZED CELL (red), UNPOLARIZED CELL (gray), MATRIX (white), and LUMINAL SPACE (black). At the top, selected decision-making CELLS at the start of simulation cycle n are numbered to indicate each of the twelve axiomatic preconditions being satisfied (they are listed in Table 1). For purpose of this illustration, the unnumbered CELLS are inactive. At the bottom, the system at the start of simulation cycle n + 1 shows the consequences of applying all twelve axioms.
Kim et al. BMC Systems Biology 2009 3:122 doi:10.1186/1752-0509-3-122