Figure 8.

Prediction of genetic targets for improved fructofuranosidase production in A. niger based on the target validity coefficient. The target validity coefficient was obtained from correlation of flux through metabolic reactions with fructofuranosidase production flux within the calculated elementary modes. A positive value (green colour) relates to a reaction, which positively correlates with the production, whereas negative correlation is indicated by a negative value (red colour). Black colour indicates statistically insignificant values (no correlation = nc). The investigated biological scenarios comprise growth- (+) and non-growth-associated production (-) on glucose (Glu), glycerol (Gly), xylose (Xyl) and oleate (Ole) as carbon source. The absolute values for the target validity coefficients together with statistical information are additionally available in the supplementary material (Table A2 -- A7).