Additional file 1:

Supplementary Material. This file (supplment.pdf) contains the material which is not given in the paper due to the space limitations. This file consists of three parts. Section 1 outlines some technical aspects of the methodology described in the paper. Section 2 presents the results obtained in the full search case. It includes plots for model responses compared to the data, scatter plots of parameters, plots of the confidence intervals for parameter estimates, discussion about the correlations between parameters, and results of parameter estimation with fixed weight for regulation of kni by Hb. Section 3 presents the results in the case of fixed promoter thresholds, including plots for model responses compared to the data, scatter plots of parameters, plots of the confidence intervals for parameter estimates, and discussion about the correlations between parameters.

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