Table 7 |
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|
Reaction rules for the considered example of EGF and insulin receptor crosstalk. |
|||||
|
IR(0, 0, *, *) |
+ |
Ins |
⇋ |
IR(I, 0, *, *) |
k1, k-1 |
|
IR(0, 0, *, *) |
+ |
Ins |
⇋ |
IR(0, I, *, *) |
k1, k-1 |
|
IR(I, 0, *, *) |
+ |
Ins |
⇋ |
IR(I, I, *, *) |
k2, k-2 |
|
IR(0, I, *, *) |
+ |
Ins |
⇋ |
IR(I, I, *, *) |
k2, k-2 |
|
IR(0, 0, 0, *) |
⇋ |
IR(0, 0, P, *) |
k3, k-3 |
||
|
IR(I, 0, 0, *) |
⇋ |
IR(I, 0, P, *) |
k4, k-4 |
||
|
IR(0, I, 0, *) |
⇋ |
IR(0, I, P, *) |
k4, k-4 |
||
|
IR(I, I, 0, *) |
⇋ |
IR(I, I, P, *) |
k5, k-5 |
||
|
IR(*, *, P, *) |
+ |
Shc(*) |
⇋ |
IR(*, *, Shc(*), *) |
k6, k-6 |
|
IR(I, I, Shc(0), *) |
⇋ |
IR(I, I, Shc(P), *) |
k7, k-7 |
||
|
IR(*, *, Shc(P), *) |
+ |
Grb2(*) |
⇋ |
IR(*, *, Grb2(*), *) |
k8, k-8 |
|
IR(*, *, Grb2(0), *) |
+ |
SOS(0) |
⇋ |
IR(*, *, SOS(0), *) |
k9, k-9 |
|
IR(*, *, Grb2(0), *) |
+ |
SOS(P) |
⇋ |
IR(*, *, SOS(P), *) |
k10, k-10 |
|
IR(*, *, SOS(0), *) |
⇋ |
IR(*, *, SOS(P), *) |
k11, k-11 |
||
|
IR(0, 0, *, 0) |
⇋ |
IR(0, 0, *, P) |
k12, k-12 |
||
|
IR(I, 0, *, 0) |
⇋ |
IR(I, 0, *, P) |
k13, k-13 |
||
|
IR(0, I, *, 0) |
⇋ |
IR(0, I, *, P) |
k13, k-13 |
||
|
IR(I, I, *, 0) |
⇋ |
IR(I, I, *, P) |
k14, k-14 |
||
|
IR(*, *, *, P) |
+ |
IRS(*) |
⇋ |
IR(*, *, *, IRS(*)) |
k15, k-15 |
|
IR(I, I, *, IRS(0)) |
⇋ |
IR(I, I, *, IRS(P)) |
k16, k-16 |
||
|
IR(*, *, *, IRS(P)) |
+ |
Grb2(*) |
⇋ |
IR(*, *, *, Grb2(*)) |
k17, k-17 |
|
IR(*, *, *, Grb2(0)) |
+ |
SOS(0) |
⇋ |
IR(*, *, *, SOS(0)) |
k9, k-9 |
|
IR(*, *, *, Grb2(0)) |
+ |
SOS(P) |
⇋ |
IR(*, *, *, SOS(P)) |
k10, k-10 |
|
IR(*, *, *, SOS(0)) |
⇋ |
IR(*, *, *, SOS(P)) |
k11, k-11 |
||
|
Shc(0) |
⇋ |
Shc(P) |
k18, k-18 |
||
|
Shc(P) |
+ |
Grb2(*) |
⇋ |
Shc(Grb2(*)) |
k8, k-8 |
|
Shc(Grb2(0)) |
+ |
SOS(0) |
⇋ |
Shc(SOS(0)) |
k9, k-9 |
|
Shc(Grb2(0)) |
+ |
SOS(P) |
⇋ |
Shc(SOS(P)) |
k10, k-10 |
|
Shc(SOS(0)) |
⇋ |
Shc(SOS(P)) |
k11, k-11 |
||
|
Grb2(0) |
+ |
SOS(0) |
⇋ |
Grb2(SOS(0)) |
k9, k-9 |
|
Grb2(0) |
+ |
SOS(P) |
⇋ |
Grb2(SOS(P)) |
k10, k-10 |
|
Grb2(SOS(0)) |
⇋ |
Grb2(SOS(P)) |
k11, k-11 |
||
|
SOS(0) |
⇋ |
SOS(P) |
k19, k-19 |
||
|
IRS(0) |
⇋ |
IRS(P) |
k20, k-20 |
||
|
IRS(P) |
+ |
Grb2(*) |
⇋ |
IRS(Grb2(*)) |
k17, k-17 |
|
IRS(Grb2(0)) |
+ |
SOS(0) |
⇋ |
IRS(SOS(0)) |
k9, k-9 |
|
IRS(Grb2(0)) |
+ |
SOS(P) |
⇋ |
IRS(SOS(P)) |
k10, k-10 |
|
IRS(SOS(0)) |
⇋ |
IRS(SOS(P)) |
k11, k-11 |
||
|
ER(0, *, *) |
+ |
EGF |
⇋ |
ER(E, *, *) |
k21, k-21 |
|
ER(*, 0, *) |
⇋ |
ER(*, P, *) |
k22, k-22 |
||
|
ER(*, P, *) |
+ |
Shc(*) |
⇋ |
ER(*, Shc(*), *) |
k23, k-23 |
|
ER(*, Shc(0), *) |
⇋ |
ER(*, Shc(P), *) |
k24, k-24 |
||
|
ER(*, Shc(P), *) |
+ |
Grb2(*) |
⇋ |
ER(*, Grb2(*), *) |
k8, k-8 |
|
ER(*, Grb2(0), *) |
+ |
SOS(0) |
⇋ |
ER(*, SOS(0), *) |
k9, k-9 |
|
ER(*, Grb2(0), *) |
+ |
SOS(P) |
⇋ |
ER(*, SOS(P), *) |
k10, k-10 |
|
ER(*, SOS(0), *) |
⇋ |
ER(*, SOS(P), *) |
k11, k-11 |
||
|
ER(*, *, 0) |
⇋ |
ER(*, *, P) |
k25, k-25 |
||
|
ER(*, *, P) |
+ |
Grb2(*) |
⇋ |
ER(*, *, Grb2(*)) |
k26, k-26 |
|
ER(*, *, Grb2(0)) |
+ |
SOS(0) |
⇋ |
ER(*, *, SOS(0)) |
k9, k-9 |
|
ER(*, *, Grb2(0)) |
+ |
SOS(P) |
⇋ |
ER(*, *, SOS(P)) |
k10, k-10 |
|
ER(*, *, SOS(0)) |
⇋ |
ER(*, *, SOS(P)) |
k11, k-11 |
||
|
ER(E, *, *) |
+ |
ER(0, *, *) |
⇋ |
ER2(E, *, *, 0, *, *) |
k27, k-27 |
|
ER(0, *, *) |
+ |
ER(0, *, *) |
⇋ |
ER2(0, *, *, 0, *, *) |
k28, k-28 |
|
ER(E, *, *) |
+ |
ER(E, *, *) |
⇋ |
ER2(E, *, *, E, *, *) |
k29, k-29 |
|
ER2(0, *, *, *, *, *) |
+ |
EGF |
⇋ |
ER2(E, *, *, *, *, *) |
k30, k-30 |
|
ER2(*, 0, *, *, *, *) |
⇋ |
ER2(*, P, *, *, *, *) |
k31, k-31 |
||
|
ER2(*, Shc(0), *, *, *, *) |
⇋ |
ER2(*, Shc(P), *, *, *, *) |
k32, k-32 |
||
|
ER2(*, P, *, *, *, *) |
+ |
Shc(*) |
⇋ |
ER2(*, Shc(*), *, *, *, *) |
k23, k-23 |
|
ER2(*, Shc(P), *, *, *, *) |
+ |
Grb2(*) |
⇋ |
ER2(*, Grb2(*), *, *, *, *) |
k8, k-8 |
|
ER2(*, Grb2(0), *, *, *, *) |
+ |
SOS(0) |
⇋ |
ER2(*, SOS(0), *, *, *, *) |
k9, k-9 |
|
ER2(*, Grb2(0), *, *, *, *) |
+ |
SOS(P) |
⇋ |
ER2(*, SOS(P), *, *, *, *) |
k10, k-10 |
|
ER2(*, SOS(0), *, *, *, *) |
⇋ |
ER2(*, SOS(P), *, *, *, *) |
k11, k-11 |
||
|
ER2(*, *, 0, *, *, *) |
⇋ |
ER2(*, *, 0, *, *, *) |
k33, k-33 |
||
|
ER2(*, *, P, *, *, *) |
+ |
Grb2(*) |
⇋ |
ER2(*, *, Grb2(*), *, *, *) |
k34, k-34 |
|
ER2(*, *, Grb2(0), *, *, *) |
+ |
SOS(0) |
⇋ |
ER2(*, *, SOS(0), *, *, *) |
k9, k-9 |
|
ER2(*, *, Grb2(0), *, *, *) |
+ |
SOS(P) |
⇋ |
ER2(*, *, SOS(P), *, *, *) |
k10, k-10 |
|
ER2(*, SOS(0), *, *, *, *) |
⇋ |
ER2(*, *, SOS(P), *, *, *) |
k11, k-11 |
||
|
|
|||||
|
Conzelmann et al. BMC Systems Biology 2008 2:78 doi:10.1186/1752-0509-2-78 |
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