Open Access Research article

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach

Najl V Valeyev1*, Declan G Bates1, Pat Heslop-Harrison12, Ian Postlethwaite1 and Nikolay V Kotov3

Author Affiliations

1 Systems Biology Lab, Department of Engineering, University of Leicester, University Road, Leicester, LE1 7RH, UK

2 Systems Biology Lab, Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK

3 Biophysics & Bionics Lab, Department of Physics, Kazan State University, Kazan 420008, Russia

For all author emails, please log on.

BMC Systems Biology 2008, 2:48  doi:10.1186/1752-0509-2-48

Published: 2 June 2008

Additional files

Additional file 1:

The relationship between the Adair and independent binding models. The relationship between macroscopic constants derived from the Adair equation and the proposed Ca2+-CaM binding model with free Ca2+ access.

Format: PDF Size: 27KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data