Renal and hepatic insulin clearance. Insulin clearance is defined as the quotient of insulin degradation rate and insulin concentration. Total stationary insulin clearance (black) is a function of insulin concentration because hepatic insulin clearance (liver, red) depends on the insulin concentration, whereas renal insulin clearance (kidney, blue) is independent of insulin concentration. A body weight of mbody = 200 g was used in the computations.
Koschorreck and Gilles BMC Systems Biology 2008 2:43 doi:10.1186/1752-0509-2-43