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Open Access Highly Accessed Research article

Mathematical modeling and analysis of insulin clearance in vivo

Markus Koschorreck* and Ernst Dieter Gilles

Author Affiliations

Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany

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BMC Systems Biology 2008, 2:43  doi:10.1186/1752-0509-2-43

Published: 13 May 2008

Additional files

Additional file 1:

In vivo model. This file contains a MATLAB model to simulate in vivo experiments.

Format: M Size: 4KB Download file

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Additional file 2:

In vitro receptor model. This file contains the receptor part of the in vivo model and can be taken to simulate in vitro experiments with a constant insulin concentration.

Format: M Size: 2KB Download file

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Additional file 3:

Robustness and parameter estimation. This file describes the examination of robustness to changes in parameter values and the estimation of the model parameters.

Format: PDF Size: 235KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional file 4:

Stationary model analysis. In this file, the stationary model equations are analyzed.

Format: NB Size: 296KB Download file

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Additional file 5:

Stationary model analysis in portable document format. This file is equivalent to Additional file 4 but results from a conversion to PDF.

Format: PDF Size: 48KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional file 6:

Stationary analysis of the model of Sedaghat et al. The stationary model equations of Sedaghat et al. [37] are analyzed.

Format: NB Size: 138KB Download file

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Additional file 7:

Stationary analysis of a modified model of Hori et al. The stationary model equations of a modified model of Hori et al. [38] are analyzed.

Format: NB Size: 80KB Download file

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