Figure 1.

Structure of the JAK2-STAT5 pathway model proposed. Legend: Epo: concentration of Epo in the extracellular medium; EJ: fraction of non-activated EpoR/JAK2 complex; pEpJ: fraction of activated EpoR/JAK2 complex; S: fraction of non-activated and non-dimerised STAT5 in the cytosol; DpS: fraction of activated and dimerised STAT5 in the cytosol; DpS_nc: fraction of activated and dimerised STAT5 inside the nucleus.