An integrated genetic, genomic and systems approach defines gene networks regulated by the interaction of light and carbon signaling pathways in Arabidopsis
1 Department of Biology, New York University, New York, NY, 10003, USA
2 Department of Biology, Messiah College, Grantham, PA, 17027, USA
3 Departamento de Genética Molecular y Microbiología, Pontificia Universidad Católica de Chile. Alameda 340. 8331010. Santiago, Chile
4 Courant Institute of Mathematical Sciences, New York University, New York, NY, 10003, USA
BMC Systems Biology 2008, 2:31 doi:10.1186/1752-0509-2-31Published: 4 April 2008
Light and carbon are two important interacting signals affecting plant growth and development. The mechanism(s) and/or genes involved in sensing and/or mediating the signaling pathways involving these interactions are unknown. This study integrates genetic, genomic and systems approaches to identify a genetically perturbed gene network that is regulated by the interaction of carbon and light signaling in Arabidopsis.
The global misregulation of gene networks controlled by light and carbon signaling in cli186 indicates that it represents one of the first Arabidopsis mutants isolated that is specifically disrupted in the integration of both carbon and light signals to control the regulation of metabolic, developmental and regulatory genes. The network analysis of misregulated genes suggests that CLI186 acts to integrate light and carbon signaling interactions and is a master regulator connecting the regulation of a host of downstream metabolic and regulatory processes.