Table 5 |
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|
Effects of increasing parameters on in silico measures. |
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|
Parameter |
Maximum size |
Viable rim width |
Quiescence onset |
Necrosis onset |
Growth rate |
Doubling time |
Stability |
Necrotic core size |
|
|
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|
DiffusionRate |
↑ |
↑ |
↑ |
↑ |
-- |
-- |
↔ |
↔ |
|
initialVal |
↑ |
↑ |
↑ |
↑ |
↓ |
↓ |
↔ |
↑ |
|
proConsumeRate |
↓ |
↓ |
↓ |
↓ |
-- |
-- |
-- |
↔ |
|
quiConsumeRate |
↓ |
↓ |
-- |
↔ |
-- |
-- |
-- |
↔ |
|
prolifDelay |
↔ |
-- |
↑ |
↑ |
↓ |
↓ |
-- |
↔ |
|
removeDelay |
↑ |
-- |
-- |
-- |
-- |
-- |
↔ |
↑ |
|
proNut |
↔/-- |
-- |
↓ |
↓ |
-- |
-- |
↓ |
↔ |
|
quiNut |
↓ |
↓ |
-- |
↓ |
↓ |
-- |
-- |
--/↓ |
|
proBias |
↓ |
↑ |
↑ |
↑ |
↓ |
↓ |
--/↑ |
↓ |
|
moveEmptyBias |
↔ |
↓/↑ |
-- |
-- |
↑ |
-- |
↑ |
↑ |
|
|
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|
↑: Positive effect. ↓: Negative effect. ↔: Effect limited or not easily determined. --: No effect. Cells with two values (e.g. --/↑) indicate different effects at high nutrient (left) and low nutrient (right). Cells with one value indicate similar effect at high and low nutrient. * Quiescence onset and necrosis onset are the measured times of onset. A positive effect indicates that the time of quiescence or necrosis onset increased, thus they occurred later in the simulation. |
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|
Engelberg et al. BMC Systems Biology 2008 2:110 doi:10.1186/1752-0509-2-110 |
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