Table 3

Intracellular pathway model. Rate equations relating to intracellular EGFR-MAPK pathway.

Species

Rate equation

Constants


11

Shc

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M11','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M11">View MathML</a>

k5 = 12

K5 = 6 × 103

12

ShcP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M12','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M12">View MathML</a>

V6= 3.0 × 105

K6 = 6 × 103

K7 = 2 × 10-3

k-7 = 3.81

13

GrbSos

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M13','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M13">View MathML</a>

K8 = 1.6;

K8 = 6 × 105

14

GrbSosP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M14','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M14">View MathML</a>

V9 = 75;

K9 = 2.0 × 104

15

ShcGrbSos

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M15','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M15">View MathML</a>

k10 = 1.63 × 10-2

k10 = 10

k11 = 15

16

RasGDP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M16','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M16">View MathML</a>

k12 = 5.0 × 10-3

k-12 = 60

17

ShcGrbSosRas

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M17','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M17">View MathML</a>

k13 = 7.2 × 102

k14 = 1.2 × 10-3

18

RasGTP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M18','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M18">View MathML</a>

k-14 = 3.0

k15 = 27

19

GAP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M19','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M19">View MathML</a>

V16 = 9.7 × 104

K16 = 6 × 103

20

RasGAP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M20','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M20">View MathML</a>

k17 = 50;

K17 = 9 × 103

21

Raf

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M21','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M21">View MathML</a>

V18 = 9.2 × 105

K18 = 6 × 105

22

RasRaf

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M22','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M22">View MathML</a>

k19 = 50;

K19 = 9 × 103

23

RafP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M23','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M23">View MathML</a>

V20 = 9.2 × 105

K20 = 6 × 105

24

Mek

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M24','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M24">View MathML</a>

k21 = 8.3;

K21 = 9 × 104

25

MekP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M32','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M32">View MathML</a>

V22 = 2.0 × 105

26

MekPP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M25','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M25">View MathML</a>

K22 = 6 × 105

k23 = 8.3;

27

Erk

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M26','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M26">View MathML</a>

K23 = 9 × 104

28

ErkP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M27','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M27">View MathML</a>

V24 = 4.0 × 105;

K24 = 6 × 105

29

ErkPP

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M28','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M28">View MathML</a>


Units are as for Table 1. All constants are taken directly from [14].

Walker et al. BMC Systems Biology 2008 2:102   doi:10.1186/1752-0509-2-102

Open Data